L-arginine actively participates in sperm formation [1].

A deficiency in L-arginine causes derangement of sperm metabolism leading to decrease in motility and loss of spermatogenesis [2].

Administration of L-arginine to oligospermic and asthenospermic patients results in an improvement in both the sperm count and motility without any side effects [3, 4].

L-arginine plays an important role in stimulating sperm motility in humans [3,5,6].

L-arginine enhances the rate of glycolysis, resulting in higher rates of ATP and lactate generation in spermatozoa [6].

L-arginine reverses impairment caused by glycolytic inhibitors (potential contraceptives). The reversal effect of L-arginine involves an eight-fold higher metabolic activity compared to inhibited cells. [7]

American Society for Cell Biology
47th Annual Meeting
Washington, D.C.

The American Society for Cell Biology presented findings by researchers at Cornell University directed at utilizing Nanotechnolgy in the biological pathway that sperm uses to generate energy.

Researchers at Cornell are working to use the same energy that drives sperm to power nanoscale robots or to deliver chemo drugs or antibiotics, for example, to targeted sites within the body.

A midsection between the head and the long tail of sperm contains mitochondria, organelles that generate a cell's power. Human sperm have also developed a second energy source to power their long tail. They employ a process known as glycolysis, which breaks down glucose to derive ATP, which cells use for energy. The pathway for glycolysis requires specific enzymes. Using special "targeting domains," sperm tether these to a fibrous sheath that runs the length of the tail.

Further research in Nanotechnology and Reproduction centers on using nanoparticles are protein carriers into sperm cells. The 2008 study and publication [Modified PVA-Fe3O4 Nanoparticles as Protein Carriers into Sperm Cells, Small 2008 Sep;4(9):1453-8] elucidates the use of Nanotechnology and sperm cells.

Researchers developed targeted nanoparticles conjugated to protein in order to serve as protein carriers into sperm cells. The conjugate comprises iron oxide nanoparticles that are covalently bound to an anti-protein kinase C (PKC) alpha antibody. The surface of the nanoparticle is first modified with (3-aminopropyl) thrimethoxysilane to form a self-assembled monolayer, and subsequently conjugated with the antibody through amidation between the carboxylic acid end groups on the antibody and the amine groups on the surface of the nanoparticles.

Nanotechnology includes the fields of Nanofoods, Nanoparticles, Nanobots, Nanoelectronics, Nanomedicine, Nanocosmetics, and Nanodrugs.

Nanodrugs allow the delivery of functional agents to targeted sites in the body. Nanofoods function in much the same manner, except instead of delivering drugs to target-sites, they can deliver specific ingredients to their targeted destinations in the human body.

Nanoparticles, another branch of Nanotechnology, allows for the transport of nutrients through membranes and across the Blood-Brain-Barrier (BBB), as well as targeted sites in the human body.

Nanoparticles can be embedded in foods or Nutraceuticals and programmed to send out an alert to refrigerator sensors that food has gone bad or contains harmful bacteria. Nanoparticles are based on Quantum Physics. Their minuscule size allows scientists to engineer particles, naturally or synthetically, so that they biochemically behave differently than normal size particles.

The main controversial issue in the development of NanoFoods is one of safety. There are currently two methods utilized in designing Nano-based edibles; soft particle science and hard particle science:

Soft particle science embraces the use of safe, human-edible-grade ingredients (non-enhanced, non-genetically-modified biological materials) imbedded or integrated into Nanofoods. Soft particles are completely safe for carbon-based mechanisms, such as mammals, including humans. The human body is adept at processing soft particles, and hold them harmless because they look like normal cells.

Hard particle science embraces the use of non-organic, synthetic substances imbedded into Nanofoods. Hard particles are potentially dangerous to life forms because the human body does not recognize them and does not know how to process them. As the body attempts to biologically process unknown agents (biosynthesize), highly toxic reactions can occur at a molecular level.

These reactions may not be evidenced immediately, but can result in kidney, liver, and organ damage, as well as life-span-reduction.

ArgMatrix™ has incorporated SOFT PARTICLE SCIENCE Nanotechnolgy into its delivery matrix. ArgMatrix™ has undergone analysis for Safe Nanoparticle Science at the Glycemic Research Institute (www.Glycemic.com) and has passed all Protocols for SAFE NANOPARTICLES.

Nanoparticles co-bonded with L-Arginine facilitates access to specific Isoform pathways in the human body. L-Arginine does not produce Nitric Oxide (NO), unless an acceptable Isoform pathway is accessed. High glycemic and non-targeted forms of L-arginine do not access said pathways in humans.

There are only four distinct paths of entry that allow Nanoparticles to enter the human body. ArgMatrix™ facilitates access through endothelial-cell-gaps. These gaps allow ArgMatrix™ molecules to pass into the blood stream, where they are carried throughout the body, and subsequently passed out of the blood into different tissues. In the brain, these endothelial cells are packed more tightly together, due to the existence of zonulae occludentes (tight junctions) between them, blocking the passage of most molecules.

Only an identified and specific transport system will allow the amino acid L-arginine to produce Nitric Oxide (NO) and to stimulate specific hormones. ArgMatrix™ nanoparticles are engineered to access this transport system, providing a carrier-mediated-transporter for the Blind Amino Acid L-arginine, with specific function in Nanoparticle biostrategy.

Since a nanoparticle is incredibly small, a delicate and complicated proprietary process is required to produce safe nanoparticles and their attendant Isoform-friendly glycosides, which attach to an L-arginine molecule. Nanoparticles possess a diameter small enough to penetrate through diminutive capillaries into the cell's internal machinery and create a pre-programmed response, thus the term Edible Computer Chip®.

ENCODE®, the global revolutionary breakthrough in L-arginine biochemistry, is utilized in the genetic-field of NutriGenomics. ENCODE® is based on L-arginine carrier-mediated-transporters in Sickle Cell disease, Thalassemia, Genetic Polymorphisms, Dysregulated Arginine Metabolism. ENCODE® utilizes the same Isoform pathway and Nanoparticles as ArgMatrix™. This technology is the result of 25-years of research in L-arginine biochemistry and Isoform pathways.

The Patented ArgMatrix™ complex defies reverse-engineering. It is currently impossible to “copy” or duplicate ArgMatrix™ due to the complexity of the development process.

The carrier-mediated-transporter system in ArgMatrix™ has additionally undergone Human In Vivo Clinical Trials in adult non-diabetics and diabetics, focusing on glycemic response, human Adipose Tissue Fat-Storage, Lipoprotein Lipase (LPL), and blood glucose/insulin response.

These statements have not been evaluated by the Food & Drug Administration. The products promoted herein are not intended to diagnose, treat, cure, or prevent any disease.